inverse miniemulsion method for synthesis of gelatin nanoparticles in presence of cdi/nhs as a non-toxic cross-linking system

نویسندگان

s. zinatloo-ajabshir

n. taheriqazvini

چکیده

in this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (cdi) and n-hydroxysuccinimide (nhs) as a non-toxic cross-linking system. the gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutaraldehyde (ga) as the most commonly utilized cross-linking agent. the results showed the formation of more homogeneous nanoparticles with smaller size when cdi/nhs used as cross-linking agent under the same synthesis condition. moreover, dilute solution viscosimetry experiments confirmed the stability of the nanoparticles under various physicochemical conditions. the differences in the characteristics of cdi/nhs and ga cross-linked nanoparticles were ascribed to the different nature of network formation using the two cross-linking agents. generally, these results suggested cdi/nhs cross-linked gelatin nanoprticles as an interesting candidate for drug delivery application.

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منابع مشابه

Inverse Miniemulsion Method for Synthesis of Gelatin Nanoparticles in Presence of CDI/NHS as a Non-toxic Cross-linking System

In this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (CDI) and N-hydroxysuccinimide (NHS) as a non-toxic cross-linking system. The gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutarald...

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Inverse Miniemulsion Method for Synthesis of Gelatin Nanoparticles in Presence of CDI/NHS as a Non-toxic Cross-linking System

In this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (CDI) and N-hydroxysuccinimide (NHS) as a non-toxic cross-linking system. The gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutarald...

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عنوان ژورنال:
journal of nanostructures

ناشر: university of kashan

ISSN 2251-7871

دوره 4

شماره 3 2014

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